I think it's more of a title than an actual "You are the last one AND THERE SHALL BE NO OTHERS!" You are the "Last Dragonborn" probably because the prophecy wouldn't sound as epic or foreshadowy if it was along the lines of "The wheel of time turns on the Dragonborn that just happens to be around at the time of Alduin's return."
Also, I think it's probably because it sounds better that the "Last Dragonborn," is fighting the "Firstborn of Akatosh." It gives a nice dichotomy and yin-yang effect to the whole struggle between the player and Alduin.
Then again, I think that the "Last Dragonborn" is actually Alduin reincarnated.
Unfortunately, that is the definition of "Last", just like Martin was the Last Septim.
I do find it as more like a marketing scheme than an actual flow of thought. Just like "The Last Airbender", being "The Last" means great hope is burdened upon you, and great things are expected from you, befitting a legendary hero. It makes you think you're special, and you'll be able to do things people normally can't, and your name will outlast the dragonborns before you.
However, it does not mean that a dragonborn is really necessary to fight the dragons. The only dragon capable of resurrecting other dragons is Alduin, and Alduin himself is no longer in this world, and there is no mention whether Paarthurnax is capable of it or not.
This means, so long as Alduin is not present, men can actually kill the dragons without worry. Their soul is eternally awake, but without a body to do harm, there is no point, just like what had happened for 3 eras