Well, in the Developers Diary, Sawyer said 'We wanted to start the play out in a cliche Vegas Style'
Beats starting off 5-7 years after a boat explosion. (Saints Row 2) :laugh:
The ending to Saints Row 1 was just - wow. It was nice to see that intro to Saints Row 2. People thought Fallout 3's ending svcked? At least you saw your death coming. Saint's Row has a mission like pretty much any other, one where you are expecting to solidify control on the city once and for all, your crowning moment of awesome . . . and the boat blows up. Roll credits.
Imagine if, in Fallout 3, you were talking to Colonel Autumn in the Purifier, and a tech screamed, "The Purifier was damaged in the fight! It's going to blow!" Cut to the outside of the Jefferson Memorial, and the whole thing goes up like Megaton. Roll credits.
As to surviving gunshots, of course it is possible. Keep in mind to that before advances in medical technology, people were often mistaken for dead, when they were, in fact, not. Often these people regained consciousness on their own. If, in fact, the package the Courier was carrying is the attacker's main focus, they could easily have shot the Courier until they stopped moving, kicked them into a shallow hole, and walked off with the package while the Courier was still very much alive, if in very bad shape. How many times in Fallout 3 have we shot a character or NPC and then walked away without checking if they are still alive (gameplay indicators not withstanding)?
Likely that the Courier just lapsed into a coma, and was nursed back from the brink by the good doctor. Though why, in the wasteland, someone would devote the considerable effort and resources to saving a complete stranger already very nearly as good as dead is a mystery. Dr. Mitchell seems far too altruistic to be trust-worthy to me. He even gives you a rare and valuable Pipboy! I suspect puppetry!