mmm.. I have several "quests" (nothing with dialog only using the alias system) and never used/needed this SEQ.
Is your recommendation based on some a new thing?
Nope. I discovered it myself. I made a quest very early on in my mod progress. SGE, Run Once etc etc as we were told in many tutorials. This quest is a quest for later in my mod.
Much later, I changed some of the alias info. Then in a save that already used my mod, the alias changes took no effect. This is because the quest is Running in the background, whether its started or not. I thought a quest had to actually be Started before no edits would change it. I was wrong.
So I recommend unless your quest needs to run at the start of the game, do not have it SGE.