Probably suggested by a ton of people already, but I personally dislike the gigantic fonts everywhere. When I'm sitting just 2 feet away from my screen, I can read everything perfectly if the font was half the size. Would make navigating items, responses and everything easier too when there are a lot more listed on screen before you have to scroll down

Other suggestions would be to reduce the compass size by half and placing it at the bottom instead of the top, and Health, Magicka, Stamina bars reduced in size and stacked on top of eachother in some corner of the screen. Lastly the skill increases could be a bit more subtle and off to the top left (or right) instead of 'in-your-face' at the centre of the screen

Oh, and if it were possible to separate Buy/Sell items that would be awesome too. I still recall wanting to sell my stuff, only to find out that I was buying the same stuff from the vendor instead

Greetz,
Milt