Master lock with ~20 skill, no problem. Well, i did break about dozen picks, but still got it open


I'll be replacing that with a real time, character skill based lockpicking mod ASAP, that would also make the perks more useful. And mod some high cost, not assured succes unlock spells back to the Alteration school.
This. This would make it very difficult to pick difficult locks with low skill level, while still keeping it possible and making perks useful.