Actually the no stimpak thing is not a bad idea at all. I've reached the level cap in Fallout 3 without ever using any and it was a fun way to play the game.
Self imposed rules are a great way to make the game at the same time more challenging and more interesting but I don't really expect the OP to agree with this statement.

EDIT: Imp's More Complex Needs looks very interesting indeed.
I have plenty of self imposed rules, like I don't sneak attack a group more than once, I don't wear power armour, I don't use food to heal, I never steal, I keep to the progression of the story (as in I don't just run straight for the Gobi rifle at the start of a new game) etc. Self imposed rules aren't bad, but they really wreck the immersion. I mean running into a group of NPCs waving my arms around to get them to attack me after I've just shot one of them from [Hidden] achieves the same results as a mod would, but surely you understand why having the NPCs react without me needing to do that would be better? And yeah, sue me for not wanting to spend 50 hours walking through empty desert without fast traveling or playing 100 hours of an RPG with the same weapon.
After that you can quit telling "us", those of us that have been trying to help you, that we are not any help.
As I've said before, I really appreciate the effort but what do you want me to do? I specifically said on 3 different occasions that I'm not looking for "hardcoe" adjustments or additional roleplay elements, and then the next post was a list of 5 different "hardcoe" adjustment and roleplay mods. Am I supposed to say "Yes, that's exactly what I'm after!" despite it being exactly what I said I didn't want?
I'm not expecting other people to go and trawl through Nexus for me, I've done that, and I'm not expecting people to make mods to my whim, I'm just asking if anyone is working on, or knows of unreleased mods that might fit the bill, like SirDrinksAlot is.
Removing 95% of all edible items. Ergo Hunger would matter.
Yeah, that's what I mean. In my opinion, the only way to get hardcoe to work as a challenging part of the game would be to strip the entire game world of all food, water, stimpaks and beds, and then place them back in one by one in very specific locations and only put back about a 1/10th of what was there before. Turn off the water from the vast majority of sinks, toilets, water fountains etc Remove all edible food from animals (maybe allow it to be eaten after being cooked). Remove any food from merchants but then add in a dialogue option to to places like the Grub and Gulp that would remove hunger and thirst for a price in a similar way to doctors, to stop you from just stockpiling food from merchants. Make food items weigh 10-15 pounds or possibly use NVSE to limit the number of food/drink items you can carry.
Do all that and you might have a system where you actually felt like you were scavanging for food and water rather than just shoveling it into your backpack, but that is a massive amount of work.