I'm betting we'll see something like VATS in the next Elder Scrolls series... I don't know exactly how would be implemented but it's just something I think will carry over in some way.
I'm also betting they add flint lock type pistols and maybe throwing weapons to the next one. Then again they are probably working on a new engine for the game.. so I guess it will totally depend on what the new engine is capable of.
Well I don't want to see Vats in the fifth Elder Scrolls, nor do I think it will be in at all. As for flintlock pistols and the like, I strongly hope they aren't implemented, but there's always a chance and I've got one of those sneaking suspicions that they could make an appearance.
I hope the - atleast core - of the engine stays mainly the same though, as I don't want them to do anything drastic and I love and trust the current engine. I hope they do something like how Oblivion changed from Morrowind. It was the same engine, but just had lots and lots of improvements and some adjustments.