I did a couple "plays" (wouldn't call them "through" cause I didn't progress too far into any of the quests) to get the hang of it, and I am technically on my "3rd play" which is turning out to be a "playthrough" meaning I intend to do as much of the game content as I can with this character.
On this one, I did not go to Concord till about Level 25 or later. I found the "cadence" of the game was much less frenetic that way. I haven't spent nearly as much time in the various settlements and the incessant Preston quests have been much less of a hassle. Relocating my main base from Sanctuary to Oberland station helped a lot too. I probably only go to a settlement apart from Oberland about once per in-game week, and Sanctuary even less often.
I think I've got maybe ONE radiant quest from a settler at Oberland in the couple hundred hours of play and the in game date is early Feb of 2288.