I think all good space/horror movies are listed, I think.
Pandorum. Not disturbing but I liked it.
For bizarre stuff, I recommend Possession, it has the Jurassic Park guy.

Cronenberg already mentioned. Ridley Scott too. I add John Carpenter. Roman Polanski is disturbing, Kubrick is disturbing, David Lynch is disturbing. I also add Alfred Hitchcock. Lars von Trier and his Riget, I was mesmerized. Great directors.
Also mixed movies I enjoyed and found disturbing:
Jacob's Ladder
The Cell
Invasion of the Body Snatchers (1978)
The Man Who Fell to Earth
Brazil
The Silence of the Lambs
The Descent
Return of the Living Dead III
I have a weak spot for Elm Street, Chucky and Final Destination movies.

Shutter Island, a little safe but not bad at all. Black Swan was well-done. Orphan was good. Splice was disturbing but it was weakly put together. Drag Me to Hell was equally disturbing and funny.
I like The Uninvited and The Skeleton Key from recent history, nice twists too.
Jeepers Creepers, 1 and 2
Perfume: The Story of a Murderer
Tideland
Primal Fear
The Others
Se7en
The Machinist
Below (2002)
Stephen King and Clive Barker have some good movie adaptations.
I think Haute Tension is worth a look. It is gory but different, it has a nice twist too.
From TV: Millennium,
Carnivàle and Dexter. - and Six Feet Under.
For generic horror:
Timber Falls was brilliant because it was comedic.

Eden Lake, I can't remember much but it wasn't too bad. I think I should watch it again, I forgot to rate it.
These low budget, limited space movies are worth watching.
Wind Chill. It could be good, it had the potential. But I liked the acting. I knew Emily Blunt only as a name before but I gotta a tell you, she is good.
Altitude (2010) They kept the tension and mystery throughout the movie. Acting was good but characters were kinda annoying.
Frozen (2010) Somewhat realistic. Acting was good but characters were stupid.

Now worst:
Tamara 2005 (Funny story, this was labeled as Final Destination in my friends collection. I watched this for a good 20 minutes arguing myself "what kind of final destination movie is this?"

)
Intermedio 2005
The Blair Witch Project (Nothing to see here, move along.)
The Descent: Part 2
Captivity
Awful:
Paranormal Activity
The Haunting
Beneath
The Cave
Saw III
Locusts: The 8th Plague
bad:
Piranha (2010)
Saw
Resident Evil: Extinction
Final Destination 2 (No suspense)
Cube
Phew, that was long.