This could really be great considering Bethesda's experiance with Fallout 3. Maybe it could be set in a postwar fortress society in the Terminator universe where mankind has finally started getting a firm hold on reclaiming a stable society and is taking the fight to the machines with their own cyberpunk style tech who dwell in the wreckage of city ruins and utopian Skynet empire type bases. There could also be those so in awe of technology they would join Skynet to have a chance to enhance their cyberpunk gear and become super human etc.
Sorry, but I don't like that idea

I'm sick and tired of ingame ruins and wreckages. I want a "clean" hi-tech metropolis, where lots of shady things happens, like in the movie Blade Runner or the Deus Ex games (even if there are some ruins in those games, sigh). Where corporate spies are the norm, bounty hunters roam the streets and where politicians are corrupt puppets. Where there are organised groups that are for/against cybernetic enhancements with religious fanaticism. And so and on, lots of different factions and lots of politics. And no ruins

Not to say that all of it needs to be in tip top shape, though. I like the idea that the http://www.youtube.com/watch?v=VCuNOMCfMD0 used, among other things (upcoming Binary Domain is the same), that the "nice" corrupt new city is just build upon the old city which now serves as a slum. But I really want a lot more "nice" areas than slum areas. And even the "nice" city can have gritty parts.