Ooh good question. I'd say there are a few.
From my first machine, the Amiga
Nebulus
Venus the Fly Trap
Paperboy
Fantasy World, Magic Land and Treasure Island Dizzy
Xenon
Getting a bit older, and onto the Atari
Monkey Island then Monkey Island 2
Cruise for a Corpse
Maniac Mansion
On the mega drive:
The Lion King
Aladdin
Mortal Kombat 2
Streets of Rage
Golden Axe
World Cup Italian '90
Sonic (1, 2, knuckles and, to an extent, 3D)
Echo The Dolphin
Jurassic Park Rampage Edition
Primal Rage
Road Rash and the much improved Road Rash 2
The SNES:
Super Mario All Stars collection, primarily 3, though I have memories of them all
Donkey Kong Country
Some game where you would turn into some sort of werewolf. Isometric, played co-op. Beast-something, I think.
Then getting older and into the mid-teens. Looking at the N64 and goldeneye, ocarina of time, that sort of thing. And PC games came along with Counter Strike and Conflict Freespace. At this point there gets too many to talk about and I'm sure that most of mine will be the same as most of yours.
I think of all of them, Monkey Island is the one that really sticks out, along with Cruise For A Corpse. I loved that game, even if I never finished it.