If you were born with some disability, wouldn't you want to overcome it? If you had a weak immune system, wouldn't you want to make it strong?
Sleep is not a disability. (In reference to the cyborg thread, death, is also not a disability). I'm all for medicines, science, engineering and the rest, but look for example at the American NIH. They've declared a war on death- a war that they will lose. It's a fine line between striving to increase the quality of life and wasting money building a medical bridge to nowhere. Should we spend time and money developing technology to overcome disabilities? Of course. Should we equate disability with inconvenience? No. An infinite amount of time and resources cannot overcome all of the world's obstacles. It's an enlightenment folly to think that the Train of Reason can chug along and bring us to the end of discomfort, and that disease, poverty, and even death will eventually be solved by technological progress.
I believe in the Stoic maxim - "Live according to nature" without buying into Rousseau's Romanticism. I'm not a Luddite. But will being awake 24/7 make me a happier person? A better person? Would I want to end up like the bad guy in
007: Die Another Day? (

)
And while I'm on Stoicism, I see a lot of people lamenting the apparent fact that their time in life is too short. I'll remind you of some words from Seneca's
On the Brevity of Life: "Life is not short, but we who make it so."