If by effort you mean "boring repetition".
And yes, there IS direct comparison. Having to manually walk your loot back and forth could likewise be considered "reward for effort", as in, the "effort" of your having to manually transport the loot in order to keep/sell it all. Works that way in real life too. In fact, maybe they should take "fast travel" out of the game just so you will be forced to "earn" that loot you're transporting, same way you think other people should be forced to "earn" the loot they find by having to manually search through an endless supply of containers. It. Is. The. Same. Principle.
There is no depth to being forced to walk through a place you've already traversed- especially when there was nothing there anyway.
There IS however, depth in searching through the various crates and boxes. You might be looking for a sensor module to give to casdin or to rothchild, or to use in bottlecap mines. You could be looking for nuka colas to synthesize quantum. You could be looking for surgical tubing for your dart gun.
Do I take this fission battery or leave it here in this box? I wouldn't be thinking about this unless I searched. The knowledge that there could be something good inside any box leads me to explore and examine my surroundings closely- I wouldn't want to miss anything! My problem with your idea is it rewards players who are unobservant and too lazy to pay attention to their surroundings. "Here, press this button and have everything handed to you."
Like I said, it worked for Mass Effect, because mass effect wasn't about exploring and scavenging, it was about killing mercs and husks and geth and kicking reaper butt, as well as advancing the story through dialogue. The inventory was a means to that end and not emphasized. Still, there were crates that you had to manually search, so there was a bit of scavenging done.
Forget it, you obviously don't have an open mind about this. Hopefully someone working on the game will actually see my idea and understand the logic behind it. I'm outta here.
I for one am glad that those making this game are in all likelihood far too smart to implement such a lazy and intellectually insulting concept into this game. Trust me, your idea isn't new, by your own admittance. If it was right for this game it would have already been done.