Kinda skimmed the thread, so I'm not sure if this was brought up yet, but maybe some of these quests are similar to those found in WoW.
What I mean is some quests are along the lines of "Go find Jack the Whacked in Ghoulsville" and talking to Jack ends that particular quest.
Yeah, WoW and Oblivion have similiar quests.
They are just padded grinding, but WoW's appeal is that you progress, I spent 60 hours in Oblivion and got to level 8.
WoW works because you feel accomplished, it doesn't work with the Havok engine IMO.
F3 didn't have the grinding quests, so it worked, I assume neither will NVegas.