Sure. I tend to skip DLC alot of the time.
Heck, I only have two DLC between Fallout 3 and NV (and it only would have been one - Pitt - if I could have gotten a $10 MS points card. And I don't bother installing either DLC anymore.... Pitt's not worth repeating again, and BS just screws up the game).
Oblivion? Didn't bother getting any of the extras until I picked up the GotY disk, that included KotN and SI. And that was years after I got Oblivion originally.
Based on my experience with previous Beth games, odds are I won't bother with Skyrim's DLC.
