Marcy Long ticks me off until she starts to actually not mind living in Sanctuary "You know, this place isn't that bad. I mean... it's still a hole, but it could be worse." I think she says this as the happiness of the settlement rises. She's still snippy from time to time, but I placed the farm far from the shanty-town, so interactions are minimal.
I actually don't mind Jun or Preston. I can't get Preston to join me in my travels this play through however... he just wants to hit the Castle.
Mama Murphy though... "Hey *wheeze* Kiiid. Whaaatcha *wheeze* doing *wheeze* about yourrr *wheeze* searrrrrrrrch? Bring me some more *wheeze* chemmmsss so *wheeze* the sssighhhhht *wheeze* will paint a *wheeze* clearer *wheeze* pichur." And then when she's talking to anyone else she can actually speak a full sentence normally.
She easily takes thrice as long as anyone else to say anything. Like, I haven't found a way to skip dialogue, so I just walk away and get a drink, take a leak, look at AO material in between dialogue choices.