There are lots of pointless locations, but you don't know they are pointless until you scrounge around. Most will have something, but you can't realistically expect there to be a hidden unique weapon or armor at every spot you visit.
True, while certainly, most locations don't really have anything really special in them I generally like to search out new locations anyway in the off chance that I'll find one which will really be rewarding. Because some really nice rewards I've found have been in places that did not seem all that special. But I have noticed the amount of locations that really don't seem to warrant their own map markers does seem to be higher than Fallout 3, though to be fair, that does make them convenient locations to fast travel to, which really seems to be the only purpose some locations serve. I mean, at one point I found a gas station with its own map marker and I couldn't even enter the building, the doors were just boarded up, that just seems kind of pointless to me. So yeah, not every location needs to have something really special in it, but I'd certainly say there are some locations that are just kind of pointless. It's not even like there's not enough to do. It just kind of baffles me that they chose to mark some locations when there's really nothing there worth marking.
Of course, I'd also argue that some of the most interesting locations I've found aren't necessarily ones that really have any exceptional loot in them. Some locations are just interesting because they stand out from others, maybe because there's some notable landmark there, or maybe they're just so random that it feels worth exploring them just for the sake of doing so. One location that caught my attention which I found today was the
, just a crashed car out in the wastes, yet it was marked on the map. No quests involved with it, to my knowledge, and I didn't find any really great loot there. But it seemed like an interesting reference to Fallout 2, which I assumed it was meant to be.
On the other hand, though, there's also locations that I thought really deserved to have their own markers, yet, for some reason, do not. Like say, the Lucky 38, really, I'd say every section of the strip should have had its own marker. Because it's kind of annoying that to get to my presidential suite there, I need to fast travel to the north gate of the strip (Which actually puts me in Freeside outside the gate.) walk through the gate to the Strip, thus waiting through another loading screen after I just sat through the one for fast traveling, and then I still need to enter the Lucky 38 and take the elevator up to the suite. Of course, that isn't a problem anymore since I downloaded a mod which adds a map marker for it as well as some other Strip locations, but that's a luxury console players don't have. And while needing to go through one extra loading door wouldn't be that bad if it's a one time thing, since the Lucky 38 serves as my main player home, I'm going to be visiting a lot, so I want it to be as convenient as possible, anything that adds unnecessary inconvenience to getting there is rather annoying. And it's even worse if I want to visit some of the other locations in the Strip, as after entering the Strip, I'd need to walk from the north gate, through one or two more gates before I could reach then.
If it's important, it's basically guaranteed that there's more than one way to reach it in New Vegas. Unique plasma rifle? 100 hacking, 100 lockpick, or go up two flights of stairs to fight past or luck check robots to get a key.
Well, that depends on what your definition of "important" is. If you're like me and feel the need to pick up anything of value you find in an RPG, even just missing out on a normal plasma rifle because of not having enough skill would be a problem. And whenever I see containers or doors I can't open due to lack of skill, it just serves to taunt me, but that's fine, as that sort of thing makes me feel motivated to put points into the appropriate skills.