We're definitely aware that some of you are having issues here and we're planning to resolve this issue in a future update.
I have played many scenarios around this issue and it appears to be related to entering Hogar Square
Mine crashes every time I enter and then exit the Doctors House - regardless of whether I have been to the Distillery first or not and regardless of whether I have encountered the 3 assassins yet or not.
I then reloaded and skirted around the square and got the key to the Art Dealers house - I could still enter and exit the Disterillery without problems. However, after entering Hogar Square the game crashes if you try to enter/exit the Distillery as well as if you try to enter/exit the Doctor's House.
You have now been asked many times when the patch/update will be available and singularly failed to answer
You also imply this is not urgent by saying that "some of us are experiencing issues" - This is a fundamental flaw in what could otherwise be the GOTY - and it is not feasible to "play around the side mission" as you miss so much.
I am more than happy to provide more detail and/or play through various scenarios to help as I am desperate to get back to the game !
For info, I did the Granny Rags side mission and did poison the still - for this I got 2 runes - I "stole" the one from her garden and then she rewarded me with one in her front room.
Please can you give us some indication as to when you hope to have a patch ?