The first time I did not know what to expect, so I used my normal tactics against deathclaws- Riot Shotgun at point blank until the mutha is dead. This failed epicly. I lasted 20 seconds I think. It even killed me and Boone within the same hit.
Second time I tried it, I threw my big guns out- Holy Frag Grenades. Needless to say, it killed me and it.
Third time, I ran in there is my favorite weapon- The Mysterious Magnum. Wearing my duster, 1st Recon Beret, and Authority Glasses, I gunned it down in six shots, all six being criticals. Boone still got knocked out though