It was Crusader Kings II, i'm not sure I'll enjoy anything else that's coming out this year as much as I do CK II but I'd have to say probably the new Hitman game. I was looking forward to Resident Evil: Operation Raccoon City but I've heard nary a kind word in it's favor.
What's been on my mind the most lately is Dishonored, Prey 2, Guild Wars 2, and Double Fine Adventure (though it wouldn't surprise me if that one is delayed to 2013).
Starbound and Risen 2 at the moment. I don't keep up with gaming news though, so I'm usually pleasantly surprised when a game I had been interested in but forgot about suddenly is released.
Wasteland 2 (Assuming it releases in 2012, which I doubt ) Bioshock Infinite SimCity 5 (it's being released in 2013. I just remembered ) Assassin's Creed III
That and the pre-orders become available next month and Anet are not the type of devs to have the game come out 9 months after the pre-order. I suspect it'll be coming out this summer.
Nothing much, just waiting for updates for the SoaSE: Rebellion beta (dat Titans! ). Also if the next Starcraft 2 chapter is released this year, that too. Other than that, i play it by the ear