ME3
Probably Borderlands 2 after that.
If your answer isn't Diablo 3 or Torchlight 2 you should be ashamed of yourself.
I'm still looking forward to D3, but my interest was much higher back before the "constant online", "cash auction", and "no mods" things.
I played D2 99% solo and offline, and I extended it's life a great deal with massive conversion mods that changed classes, gave new types of loot, added new scenarios, etc. (not maphack and crap like that.)
And Torchlight's nice, but it was just FATE with a bit more polish. Not a truly amazing game, just a very good one. Not expecting too much more from T2 (disclaimer: haven't really been following production on it).