I'll start with a few I've seen so far:
1. Thieves Guild armor problems - there needs to be some way implemented for people to get around this. It should even be doable for those who already ran into the problem and saved afterwards by just allowing us to trade with Tonilia even if we haven't swapped armor with her and she should have the regular Thieves Guild armor as a purchaseable item.
2. The first autosave that's created when you start a new game should take up a totally brand new save slot. If it needs to overwrite an existing slot then players should be given the option of choosing which slot to overwrite. Loads of people have lost major gameplay time due to this little surprise.
