Download http://www.ntcore.com/exsuite.php, open TESV.exe in http://www.ntcore.com/exsuite.php, look down the left hand column for "File Header", click in, in the right window where it says "Click here"; click, in the list shown, check/tick "App can handle >2gb address space.
Save file overwriting the old TESV.exe(best make a back up of the old one first), once complete, start the game using "TESV.exe"; problem solved!
You're wrong, and the dude below is right
Agreed, I use CFF Explorer to manually patch, TESV.exe will NOT launch no matter what.
I use CFF Explorer to manually patch the exe and make it large address aware. This is to prevent crashes and use the capability of the big rig I had built for Skyrim.
The new patch makes the exe require Steam to launch it.
When I allowed the new Bethesda patch to apply, I then went to the new TESV. exe and made that large address aware, and then tried to run the game THROUGH STEAM, it errored. With the new patch, you can therefore neither run direct from the exe nor can you make it large address aware. Well ypu can, but if you do, it won't run.
Oh yes Bethesda, you have royally fubared PC users wishing for a stable game.