Yes. On the first playthrough, and many after for sure. I don't agree with people saying I'll miss out on the exploration. I don't lose anything vs playing with reload. I'm just more cautious, and more excited, knowing that my next step could be my last.
100% completion and Achievements aren't why I play games, I play to enjoy and this gives me the most enjoyment out of my games.
Nobody is wrong here, there is only opinions. You play your way, I'll play my way, and if I really get the desire (unlikely as it is) to go for Completionism, I'll just start a new game.
I can't wait for someone with more time than me start a dedicated thread. Or convince someone to agree to a DEDICATED THREAD!!

Too true.
I feel like DID helps put the RP back in the RPG.
Playing games like Oblivion and Fallout 3, I one day came to the realization that I was treating it too much like a game with that completionist aspect. I was too worried about making sure to talk to
every NPC, look in
every nook and cranny of an area for items, to complete
every quest that could possibly be offered.
Kind of like playing an MMO when you first roll up into a new town and make a beeline towards every questgiver to accept every quest all at once just for the sake of getting max exp/hour or available loot.
And it just... it didn't feel at all like roleplaying anymore. I kept asking myself why, and realizing more and more it made my character seem pretty neurotic. Imagine showing up to a new town talking to every single stranger on the street, doing any little thing they ask for any reason.
Sure, maybe doing all the questlines possible in one playthrough is ideal for some, but in the end it doesn't really do it for me anymore. Say you get 10 uber weapons, in the end you'd probably stick with one anyway. If instead you do the quest that makes the most sense to your character's background, skills, and disposition, it can feel that much more meaningful to reap the rewards.
Basically the best, most concise way I can put it is for roleplaying purposes. Immersion. Really crafting a unique story for each individual character instead of constantly making it "Go to A, B, C to get these quests, then in the next town go straight to X, Y, and Z to get the next batch of quests, rinse and repeat."
Hm, but I realize now this has less to do with DID specifically and more with this argument sprouting up that DID means you'll be missing out on things. Thus, my response is, I'm fine with that. I want it to play out naturally, and just try something different with each new character anyway. It's an offline RPG. I don't have to worry about min-maxing to keep up with the crowd and get parties.