My successful DID playthrough on New Vegas is the most fun I've ever had with a video game, and doing some of the DLCs blind only made it more rewarding.
Games like these always tend to be too easy anyways. But when one death or one mistake means the end of your character for good? Hell, you could sneak into a cave that houses nothing but a mudcrab and it'd still be heartpounding.
Hell, I can't even go back to non-DID gameplay. It just feels stupid to me to keep playing a character and become super-powerful with that character when I know that their true fate saw them dying to bandits at level 7 or whatever. It's one thing to make a super powerful character, it's another to know that that character truly survived to see the day that they became a demi-god.