Saren? Just bring a biotic squadmate along and have them use lift or singularity, then pinata him. Rinse repeat. Warp helps too.
It's actually a pretty easy fight, mostly because of how OP biotics are in that game.
Better still, just swap out all your ammo upgrades for the highest-levelled proton rounds you possibly can. From what I found, so long as you keep moving Saren's strongest card is his shields, and the shield bypass on the rounds will virtually eliminate that advantage. All in all, I found Saren to be one of the easier bosses I've had to face.
But here are some I absolutely hate (some spoilers):
- Duriel from Diablo II (I agree with a previous poster that they are a cheap foe...)
- Uldred from Dragon Age: Origins (it seems the only way to survive is by cheaply running in circles as your comrades fire arrows...and that's *before* factoring in the regeneration)
- All but the last of the bosses from Deus Ex: Human Revolution (why must I be forced to fight? Why are these guys apparently immune to live bullets/takedowns?)
- El Diablo from Desperadoes (I thought this was a strategy game?!)
- The Mithalan God, from Aquaria (even when you work out the winning strategy, it isn't that easy to pull off)