Game: Mass Effect 2
Character: Turian Councilor
"Ah yes, "reapers". The immortal race of sentient starships allegedly waiting in dark space. We have dismissed that claim."

Game: Return to Zork
Character: Boos Miller
http://youtu.be/iHKKq7kMF8w

Game: Oblivion
Character: Adoring Fan
"By Azura! By Azura! By Azura!"


I love how Cedric always warns you.... after it's too late and you're already dead.

Aww... I wanted to post that.

Sander Cohen from BioShock:

The Wild Bunny by Sander Cohen: I want to take the ears off, but I can't. I hop, and when I hop, I never get off the ground. It's my curse, my eternal curse! I want to take the ears off but I can't! It's my curse! It's my [censored] curse! I want to take the ears off! Please! Take them off! Please!

Got two from GMan. Copy pasted from IMDb:

G-Man: Rise and shine, Mr. Freeman. Rise and shine. Not that I wish to imply you have been sleeping on the job. No-one is more deserving of a rest. And all the effort in the world would have gone to waste until... well, let's just say your hour has come again. The right man in the wrong place can make all the difference in the world. So, wake up, Mr. Freeman. Wake up and smell the ashes


[G-Man has just frozen time at the end of the game, finishes Alyx's phrase cut off in the process]
G-Man: Time, Dr. Freeman? Is it really that time again? It seems as if you only just arrived. You've done a great deal in a small time span. You've done so well, in fact, that I've received some interesting offers for your services.
[G-Man picks something off the frozen body of Alyx]
G-Man: Ordinarily, I wouldn't contemplate them... but these *are* extraordinary times.
[the world around Gordon fades away, into the familiar "Star Tram" from Half-Life 1]
G-Man: Rather than offer you the illusion of free choice, I will take the liberty of choosing for you... if and when your time comes round again. I do apologize for what must seem to you an arbitrary imposition, Dr. Freeman. I trust it will all make sense to you in the course of... well... I'm really not at liberty to say. In the meantime... this is where I get off.
[G-Man walks away from Gordon, adjusts his tie, and walks into a white opening]


one more, every Elder Scrolls fan should know:

By Azura, by Azura, by Azura!

Kudos if you read it in his voice.

Final Fantasy XIII

"You think you just die and everything'll be sugar and rainbows?!" —Sazh

my sig

"It is pitch dark. You are likely to be eaten by a grue."

and this one from fallout 3 narration by Ron Perlman follows.

“War. War never changes.

War, war never changes. Since the dawn of humankind, when our ancestors first discovered the killing power of rock and bone, blood has been spilled in the name of everything. From God, to justice, to simple psychotic rage. In the year 2077, after millenia of armed conflict, the destructive nature of man could sustain itself no longer. The world was plunged into an abyss of nuclear fire and radiation. But it was not, as some had predicted, the end of the world. Instead, the Apocalypse was simply the prologue to another bloody chapter of human history. For man had succeeded in destroying the world. But war, war never changes.

Wheatley in Portal 2:

"If anybody asks, tell them that the last time you were down here, everybody looked pretty much alive."

"You have a minor case of serious brain damage."

There's a lot I could quote from Portal 2; if it's supposed to be funny, it is.




I totally forgot about that part.

My favorite is the one in my signature.

The stone cannot know why the chisel cleaves it;
the iron cannot know why the fire scorches it.
When thy life is cleft and scorched, when death and despair leap at thee,
beat not thy briast and curse thy evil fate,
but thank the Builder for the trials that shape thee.


It's from Thief: The Dark Project. It's not actually spoken in-game but is given in a mission intro. In fact, the Thief series is nothing short of a gold mine of great quotes. Here are some of my other favorites.

http://www.youtube.com/watch?v=e2ehZt4wa3k


Ye shall not rob from the house I have built,
or commit any theft or unrighteousness,
lest ye be struck down and driven into the earth forthwith,
and the land of the heathen consume you




He poured his children's eyes from glass
and from steel wrought their hands
that none could escape his judgement.



In fact, pretty much anything said by Garrett, Keeper Artemus, Constantine, Karras, or Benny is a good game quote. Too bad there's far too many of them to list here.

I think we can all agree Portal 2 is just one great big epic quote.

Game: Morrowind

Character: Uncle Sweetshare

Quote: http://www.youtube.com/watch?v=N0wLUdHzBsY.

"There was even going to be a party for you. A big party that all your friends were invited to. I even invited your best friend the companion cube. Of course he couldn't come because you murdered him. All your other friends couldn't come either because you don't have any other friends because of how unlikable you are."-GLaDOS

and

"I'm a mighty thesaurus! Rawr!" - Malkavian from VtM:B

Game: L4D1

Character: Louis

Quote: "PEELZZZ HEEEEREEE"

Game: L4D2

Character: Ellis

Quote: "Brhrbrbhrururhbbrrbhrbhr"

A man chooses, a slave obeys. (Bioshock)

I'm not sure why, but its the only one I can remember.

Gah I wanted to post that one.

Game:Sly Cooper
Characters : Clockwerk and Sly Cooper

Clockwerk: Sly Cooper, you have escaped my gas chamber and destroyed my death ray. Remarkable you coopers always find a way to beat me.
Sly: Always? So that was you in the backround of all those old pictures in the Thevious Racoonious how old are you?
Clockwerk:Perfection has no age...
Sly:What? You're immortal ?
Clockwerk: Revenge is the prime ingredient in the fountain of youth, I've kept myself alive for hundreds of years with a steady diet of jealous and hate, awaiting the day when I would finally eclipse your family's thieving reputation.

http://www.youtube.com/watch?v=7JVvn8rkesg


Game: Katamair Damacy
Character: King of the Cosmos
Cosmos: " sound of record scratching"

:fallout:

Jiub from Morrowind

"Wake Up. We're Here. Why are you shaking? Are you ok? Wake up. Stand up. There you go. You were dreaming. What's your name?"

:tes:

Every line in Deus Ex.

Lots of quotes from Garrus in Mass Effect 2:

"You know me. I always like to savor the last shot before popping the heat sink." *Shepard smirks. Garrus thinks about what he just said in the context of what he and Shepard were just talking about* "Wait . . . I think that anology just went somewhere horrible."

G: "Ah, hospitals are never fun to fight through."
S: "What is fun to fight through?"
G: "Gardens, electronics shops. Antique stores, but only if they're classy."

"Hey, some women find facial scars attractive. Mind you, most of those women are Krogan./Ah, probably for the best. Women were always ignoring you and hitting on me. 'Bout time you got a fair shot."

"So this is Krogan puberty? Can't we just take him to Omega and buy him a couple dances?"

-------------------

And I've always been fond of the Argonians in Morrowind saying, "The Prey approaches . . ." and "Walk on warm sands."

You know, I really tried to think back to every game I played and find a line that stood out, but I'm seriously having trouble. I'm drawing a huge blank :/... On the other hand I can think of maybe 20 quotes from movies I love. Go figure.

Every one of Ellis' "My buddy Keith" stories from L4D2.

Also (minor Mass Effect 2 spoilers)

Game:Metro 2033

Character:Bourbon

Quote:"So that's the dead city... Welcome home, Artyom."

KOTOR2 -
Atton Rand to female Exile: "Then there was some big explosion, I was sitting here for a long time, then you showed up in your underwear and things got a lot better."

(reacting to Visquis' invitation to the Jekk'Jekk Tarr)
Atton: (Highly sarcastic) Well, at least it's not a trap.
Disciple: No, Atton! I think it may be a trap!

(KOTOR2 had so many funny lines from all npc's..darn now I want to play it again)

first thought to come to mind:

Game: Need For Speed Most Wanted. Character: Clarence Callahan("Razor"). Quote: "Bus stop's that way, champ."


additionally

Game(s): Knight of The Old Republic I and Knight of The Old Republic II. Character(s): HK-47, HK-50. Quote(s):

"Statement: Apathy is death."―A vision of HK-47 on Korriban [this one i use in real life... way too often, maybe, and agree with it, too... a bit too much, even, maybe]
"Mockery: Am I all right?..." ―HK-47 upon being reactivated by the Exile
"Mocking Query: Coorta? Coorta, are you dead yet?" ―HK-50 at Peragus II [sick but memorable]

Portal

GLaDOS Intelligence Core

http://www.youtube.com/watch?v=JAw3V8ScLeI


Portal 2

Cave Johnson

"That is not a panel. That's a crusher, we sell 'em too."


Team Fortress 2

Engineer

http://www.youtube.com/watch?v=gvdf5n-zI14

Game: Dragon Age: Origins
Character: Alistair
Quote: "She's dangerous. And evil. And meeean!" (Talking about Morrigan)

Anything from the Duke.

Surprised no one's said "Pills!" from Left4Dead