In-game text from the doomstones, as well as Dyus and Jyggalag saying the fate of CoC is unkown as he defies their logical formulae, suggest that heroes can rule their own destiny
AFTER they completed their destiny.. No matter what you do, you are force to do the Mainquest in each ES Game.
Arena - You will always get the first message about first piece of the Staff of Chaos.
Daggerfall - You are actually sent to DF to investigate which leads to the MQ.
Morrowind - You get a message from Azura about your destiny that is ahead of you.
Oblivion - The Emperor sent you with the Amulet no matter what.
Skyrim - You sent to Whiterun no matter what you do either.
No matter what, you can't dodge the MQ. You will always begin it! Thus you can't dodge your destiny!