Hrm, I've been running Skyrim for 150+ hours, had 2 CTD, a few quest related bugs (expected) but i've been playing on Ultra, no real performance drops 50-60FPS. Out of all my friends who have it on PC, none of them have had crippling problems :/ either hardware related or quest related. In fact one of them commented that some of the more amusing glitches are what makes it a Bethesda game >.>. Then again, I didn't have problems with performance with Fallout 3, Fallout: New Vegas (even though that was technically an Obsidian title) or Oblivion. Maybe I have some super luck that only extends to gamesas games.
Specs are:
Windows 7 Pro 64 bit.
Phenom II 965 BE OC'd 3.8ghz
8gb DDR3 1600 G.Skill Ripjaws Ram
XFX Radeon 6870 1gb stock
700W Coolermaster Silent Pro PSU
MSI 870-G54 Motherboard
Seagate 1TB 7200 HD
I will say I couldn't run it Ultra at all (super slow speeds) due to the shadows, fixed by an Overclock (stock is 3.4ghz)
As people have been saying there are as money hardware configurations (manufacture and otherwise) as there are gamers. It is next to impossible to test every single thing. I've encountered games that an active anti-virus actually inhibited play not due to online play, but actually having it work at all. There could be dirty registries, failing hardware, viruses (broad use of term) and a number of other issues that can be causing people all these problems. Bethesda has no sure way to test this with both deadlines and manpower. There are only hundreds of complaints on the forums from hundreds of individuals, not thousands, not 10's of thousands that have purchased this game.
Just thought I'd give it my two cents, let them have a shot at fixing the problems instead of wasting forum space with rants about how it doesn't work so great. Constructive complaints are much more useful.
EDIT:
My only complaint about the game so far is the controller optimized UI. Again, not a huge issue just annoying
